Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression
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منابع مشابه
Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression
BACKGROUND Ginsenoside-Rg3, the pharmacologically active component of red ginseng, has been found to inhibit tumor growth, invasion, metastasis, and angiogenesis in various cancer models. Previously, we found that 20(R)-ginsenoside-Rg3 (Rg3) could inhibit angiogenesis. Since microRNAs (miRNAs) have been shown to affect many biological processes, they might play an important role in ginsenoside-...
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We demonstrated previously that ginsenoside Rg(3) (Rg(3)), an active ingredient of Panax ginseng, inhibits brain-type Na(+) channel activity. In this study, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced Na(+) channel inhibition. We used the two-microelectrode voltage-clamp technique to investigate the effect of Rg(3) on Na(+) currents (I(Na)) in Xenopus laevis oocytes...
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College of Pharmacy, Inje University, 607 Obang-dong, Gimhae, Gyeongnam 621-749, Korea. *E-mail: [email protected] †Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea ‡Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, Korea §Division of Applied Biosciences, College of Agricultu...
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The authentication of the physico-chemical properties of ginsenosides reference materials as well as qualitative and quantitative batch analytical data based on validated analytical procedures is a prerequisite for certifying good manufacturing practice (GMP). Ginsenoside Rb1 and Rg1, representing protopanaxadiol and protopanaxatriol ginsenosides, respectively, are accepted as marker substances...
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Sepsis-led mitochondrial dysfunction has become a critical pathophysiological procedure in sepsis. Since ginsenosides have been applied in the treatment of mitochondrial dysfunction, ginsenoside Rg3 was employed to study its effects on the mitochondrial dysfunction induced by sepsis. The apoptosis rate, oxygen consumption rate (OCR), reactive oxygen species (ROS), antioxidant glutathione (GSH) ...
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ژورنال
عنوان ژورنال: Journal of Ginseng Research
سال: 2016
ISSN: 1226-8453
DOI: 10.1016/j.jgr.2015.07.002